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Both peptides are not approved for routine human use (sold for research purposes) and are banned in competitive sports [10]

PMID 25824066

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Novo Nordisk (24 February 2026)

However, while 16 days of L-citrulline supplementation at a daily dose of 3.4 g significantly increased plasma citrulline, arginine, and nitrite levels, and increased muscle oxygenation during moderate-intensity (70% VO 2 peak) exercise, there were no superior effects on time-to-exhaustion during high-intensity (90% VO 2 peak) exercise